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Table 7 More # of non-H, # of 2-degree cyclic atoms, degree of cyclization and # of non-H polar bonds could increase the potency of HCV NS3 Inhibitors.

From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study

Precursor Structure EC50(uM)NS3
#1
EC50(uM)NS3-2: 0.35
+ 1.94%
(× 21.3)
#1
EC50(uM)NS3-2: 0.35
+ 0.55%
(× 17.5)
#1
EC50(uM)NS3-2: 0.35
+ 0.50%
(× 17.5)
#1
EC50(uM)NS3-2: 0.35
+ 0.50%
(× 17.5)
#1
EC50(uM)NS3-2: 0.35
+ 0.37%
(× 17.5)
#1
EC50(uM)NS3-2: 0.35
+ 0.37%
(× 17.5)
#1
EC50(uM)NS3-2: 0.35
+ 0.37%
(× 17.5)
#1
EC50(uM)NS3-2: 0.35
+ 0.33%
(× 17.5)
#1
EC50(uM)NS3-2: 0.35
+ 0.23%
(× 17.5)