Table 7 More # of non-H, # of 2-degree cyclic atoms, degree of cyclization and # of non-H polar bonds could increase the potency of HCV NS3 Inhibitors.
From: Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study
Precursor | Structure | EC50(uM)NS3 | |
|---|---|---|---|
#1 EC50(uM)NS3-2: 0.35 |
|
| + 1.94% (× 21.3) |
#1 EC50(uM)NS3-2: 0.35 |
|
| + 0.55% (× 17.5) |
#1 EC50(uM)NS3-2: 0.35 |
|
| + 0.50% (× 17.5) |
#1 EC50(uM)NS3-2: 0.35 |
|
| + 0.50% (× 17.5) |
#1 EC50(uM)NS3-2: 0.35 |
|
| + 0.37% (× 17.5) |
#1 EC50(uM)NS3-2: 0.35 |
|
| + 0.37% (× 17.5) |
#1 EC50(uM)NS3-2: 0.35 |
|
| + 0.37% (× 17.5) |
#1 EC50(uM)NS3-2: 0.35 |
|
| + 0.33% (× 17.5) |
#1 EC50(uM)NS3-2: 0.35 |
|
| + 0.23% (× 17.5) |
