Figure 3

Viral RNAi screens are enriched for host factors that are subunits of human complexes. (A) All viral RNAi screens identify significantly more human complex subunits identified than expected (HIV 23%, influenza 25%, and hepatitis C 24%), compared to the number of proteins in the human genome assigned to complexes by CORUM (12%). P values shown are based on the hypergeometric distribution. We find no strong enrichment of protein complexes in a screen of Mtb host factors (13%). (B) Network of Vif interactors from GPS-Prot using the optional NIAID HIV-1-human interactions database, instead of VirusMINT. Including CORUM as a database brings complex subunits closer together in the network, for example the cluster of proteasome complex subunits shown to the lower left (e.g. PSMA, PSMB, PSMC, etc).