Figure 4
From: Ranking insertion, deletion and nonsense mutations based on their effect on genetic information
Randomization experiments. (a) Distribution of the information loss caused by the FS indels in the yeast population (blue) compared to the density of a set of randomly distributed FS indels throughout the same set of yeast genes (red). (b) Distribution of the information loss caused by the NMs in the yeast population (blue) compared to a set of randomly distributed NMs throughout the same set of yeast genes (red). (c-d) Distributions of FS indels and NMs in the human population (dbSNP [9]), respectively, with respect to the information loss they cause. For each type of variation, this distribution is different when compared to the variations with records of disease association (green) and variations that do not have such records (blue). A set of randomly generated FS indels (red) shows a similar distribution to those that are associated with diseases. (e) The distribution of DNA sites that harbour indels with respect to their LLR score is compared to the distribution of DNA sites randomly chosen from 1000 bp upstream of all genes in the yeast dataset. In panels a and b, the "randomized" histogram bars represent the mean of 100 random samplings of the data, and the error bars represent the standard deviation observed over the 100 samplings, while in panels c-e the "randomized" histogram bars represent the mean of 50 random samplings of the data, and the error bars represent the standard deviation observed over the 50 samplings.