Figure 3

Attracting states and transitions in the CPME model with deterministic reaction dynamics. [I _ex ] = 24 μM for all simulations and all other parameters as in Table 3. Panels (a) and (b): Dynamics for two cell chains that start with a cell initialized close to (a) the off-state and (b) the on-state. Panel (c): Transition from the off- to the on-state. Cell was initialized close to the off-state. A division occurs at t = 127 min. We impose V _daughter1 /V _mother = 0.15 for this division and follow the smaller daughter cell. This is the only intervention throughout the simulation. The cell reaches the on-state and remains there. Panel (d): Transition from the on- to the off-state. For this simulation and just after a DNA duplication occurring at t = 113 min, the division time is set to 50 min. An arbitrary daughter is followed, which eventually reaches the off-state.