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Table 3 DCGs with existing evidence of T2D-relevance.

From: Link-based quantitative methods to identify differentially coexpressed genes and gene Pairs

gene

DCP.dC

Expression fold change

Reported Relevance

Rapgef4

1.29

0.81

T2D-related

Nr5a1

1.28

0.56

T2D-related

Cd28

1.21

1.21

KEGG rno04940

Ucp2

1.18

1.31

T2D-related

Pparg

1.17

1.05

T2D-related; T2D-associated

RT1-Bb

1.16

0.74

KEGGrno04940

Cox6a2

1.15

0.57

KEGG rno00190

Bdnf

1.13

2.13

T2D-related

Gad1

1.12

0.23

KEGG rno04940

Prkaa1

1.12

1.03

KEGG rno04910

Prkab1

1.11

0.52

KEGG rno04910; T2D-related

RT1-Da

1.09

1.99

KEGG rno04940

Nos3

1.09

0.76

T2D-related

Cox6c1

1.09

0.62

KEGG rno00190

Inpp5d

1.08

2.36

KEGG rno04910; T2D-related

Arnt

1.07

0.71

T2D-related

Sstr5

1.06

1.77

T2D-related

Lipe

1.06

2.04

KEGG rno04910; T2D-related

Cacna1a

1.06

0.55

KEGG rno04930

RT1-Ba

1.05

1.71

KEGG rno04940

Tnfrsf1a

1.05

1.07

T2D-related

Il6

1.05

1.77

T2D-related

Gip

1.05

0.63

T2D-related

Cacna1c

1.05

0.74

KEGG rno04930

Mapk10

1.03

0.79

KEGG rno04930; KEGG rno04910; T2D-related

Nras

1.02

0.71

KEGG rno04910

Serpine1

1.02

2.07

T2D-related

Kcnj5

1.01

0.74

T2D-related

Hla-dma

1.01

2.84

KEGG rno04940

  1. Included genes appeared in at least one of the following sources: KEGG T2D-related pathways (Rno04930: type II diabetes mellitus; rno04940: type I diabetes mellitus; rno04910: insulin signaling pathway; rno00190: oxidative phosphorylation); a self-compiled set of 425 T2D-related genes in rat; a list of 52 T2D-associated genes. The lists of "T2D-related" genes and "T2D-associated" genes are provided in "Additional File 6: 52 T2D-associated genes & 425 rat T2D-related genes".