Integrating phenotype ontologies across evolutionarily divergent species. (a) Conceptual diagram depicting how multiple orthogonal phenotype ontologies (FlyBase Controlled Vocabulary, Mouse Phenotype Ontology, Worm Phenotype Ontology) can interact with each other via equivalence relationships (cross-products indicated by orange boxes). The example used here pertains to the 'cell death' process. XP stands for 'cross-product' and GO-BP stands for 'Gene Ontology Biological Process' (b) The table displays some of the phenotype annotations to genes relating to cell death anomalies in fly (Drosophila melanogaster), mouse (Mus musculus) and worm (Caenorhabditis elegans). Annotations were retrieved directly from their respective model organism databases (FlyBase, MGI, WormBase). Red font indicates conserved genes among all the depicted species. Green font shows conserved genes between D. melanogaster and M. musculus. Black font shows conserved genes between C. elegans and M. musculus.