Figure 3

A. Absolute domain architecture conservation of ortholog and paralog pairs. The average DA-score for each pair type is shown for comparisons between human and other species, sorted by their distance to human. Inparalog pairs have diverged after the speciation of the two species and are therefore generally have the most conserved domain architecture. Ortholog pairs are considerably more conserved in domain architecture than the outparalogs. B Sequence divergence of ortholog and paralog pairs. The average number of expected substitutions per position for each protein pair type is shown for comparisons between human and other species, sorted by their distance to human. The average divergence increases relatively smoothly at first within the vertebrates but a jump is seen at the vertebrate-invertebrate border.