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Table 1 Area under the semi logarithmic receiver operator curve (pROC AUC) of different rankings of residues for different targets

From: ss-TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs

Target Reference set (Ballosteros & Weinstein numbering scheme) Multi-Relief ss-TEA Theoretically optimal (top-ranked) Multi-Relief (top-ranked) ss-TEA (top-ranked)
ADRB2 3.32, 3.33, 5.42, 5.43, 5.46, 6.55, 7.35, 7.39 1.2 1.4 1.9 1.6 1.6
PI2R 2.65, 3.28, 7.39, 7.40 1.0 1.7 1.5 1.4 1.8
CNR2 3.28, 3.31, 4.64, 5.39 0.7 1.5 1.6 1.1 1.8
C5AR 3.28, 3.32, 5.39, 5.42, 5.43, 7.35 1.1 1.5 2.1 1.5 1.7
GNRHR 2.61, 2.64, 2.65, 3.32, 5.39, 6.58 1.4 1.8 1.7 1.7 1.9
V1AR 2.57, 2.61, 3.29, 3.32, 4.60, 5.43, 6.55 1.7 1.3 1.8 1.9 1.5
FFAR1 5.39, 6.55, 7.35 0.9 2.1 2.2 1.3 2.2
CCR5 1.39, 2.60, 3.32, 7.39 1.1 1.5 1.7 1.6 1.9
P2Y11 3.29, 7.39, 6.55 1.5 1.8 1.9 1.8 2.0
P2Y13 6.55, 7.35 1.0 2.1 2.2 1.4 2.2
Average 22 res total 1.2 1.7 1.9 1.5 1.9
  1. Top scoring methods are indicated in bold.