Schweder and Spjøtvoll plot. A plot of the p-value distribution for the ST data, as described in the text around Equation (8) and as suggested by Schweder and Spjøtvoll . The blue dots correspond to p-values from the moderated t-test of the m = 3486 gene pairs. For visualisation, the graph is represented by 100 points sampled equidistantly along the x-axis. The dashed straight line was fit to the values of the graph at x = 0 and x = 0.5. It intersects the x = 1 axis at y = 3014, providing an estimate of 3486 - 3014 = 472 false null hypotheses.