Assessing the correlation of functional relatedness and DIOPT score with gene ontology molecular function (GO MF) annotations. GO MF1, all GO annotations of molecular function. GO MF2, the subset of GO annotations of molecular function supported either by experimental data or author/curator statement. GO MF3, the subset of GO annotation of molecular function supported by experimental data. 2a. Correlation of functional relatedness and DIOPT score with GO MF annotations. 2b. Comparison of the functional relatedness of orthologous genes predicted by individual tools.