Quantitative utilization of prior biological knowledge in the Bayesian network modeling of gene expression data

BMC Bioinformatics

Table 6 Established pancreas gene regulatory relationships that are identified by BN modeling

Known regulatory relationship	Identified by BN modeling with prior knowledge	Identified by the plain BN without prior knowledge
Hes1→Neurog3	√
Hnf4a→Tcf1	√	√
Pdx1→Gck	√
Pdx1→Hnf4a
Pdx1→Iapp
Pdx1→Ins2	√
Pdx1→Nr5a2	√	√
Mafb→Ins2
Mafb→Pdx1
Neurog3→Nkx2-2	√
Nkx2-2→Gck	√	√
Nkx2-2→Iapp
Nkx2-2→Ins2
Onecut1→Pdx1
Onecut1→Neurog3
Onecut1→Tcf1	√
Pax6→Gck
Pax6→Iapp	√	√
Pax6→Ins2	√	√
Pax6→Pdx1	√	√
Tcf1→Hnf4a
Tcf1→Pdx1
Tcf1→Pklr
Tcf1→Slc2a2	√

BN with prior knowledge can recover half of the experimentally confirmed transcriptional regulations during mouse pancreas development, two times more than the plain BN without prior knowledge.

ISSN: 1471-2105