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Table 6 Established pancreas gene regulatory relationships that are identified by BN modeling

From: Quantitative utilization of prior biological knowledge in the Bayesian network modeling of gene expression data

Known regulatory relationship Identified by BN modeling with prior knowledge Identified by the plain BN without prior knowledge
Hes1→Neurog3  
Hnf4a→Tcf1
Pdx1→Gck  
Pdx1→Hnf4a   
Pdx1→Iapp   
Pdx1→Ins2  
Pdx1→Nr5a2
Mafb→Ins2   
Mafb→Pdx1   
Neurog3→Nkx2-2  
Nkx2-2→Gck
Nkx2-2→Iapp   
Nkx2-2→Ins2   
Onecut1→Pdx1   
Onecut1→Neurog3   
Onecut1→Tcf1  
Pax6→Gck   
Pax6→Iapp
Pax6→Ins2
Pax6→Pdx1
Tcf1→Hnf4a   
Tcf1→Pdx1   
Tcf1→Pklr   
Tcf1→Slc2a2  
  1. BN with prior knowledge can recover half of the experimentally confirmed transcriptional regulations during mouse pancreas development, two times more than the plain BN without prior knowledge.