Table 1 Examples of potentially "new" and "old" interacting pairs of proteins whose co-evolution was evaluated using two sets of organisms
From: Selection of organisms for the co-evolution-based study of protein interactions
| Â | Protein | Level9(= all) | Nearest2 | |||||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Tot/+ | AUC | Interactor (corr) | Tot/+ | AUC | Interactor (corr) |
| Â | MINE_ECOLI | Cell division topological specificity factor | 846/1 | 0.12 | MIND_ECOLI (0.52) | 223/1 | 0.83 | MIND_ECOLI (0.60) |
"recent" (BINARY_PHYS) | PABA_ECOLI | Para-aminobenzoate synthase glutamine amidotransferase component II | 671/1 | 0.28 | PABB_ECOLI (0.49) | 106/1 | 0.96 | PABB_ECOLI (0.96) |
| Â | DHAS_ECOLI | Aspartate-semialdehyde dehydrogenase | 760/1 | 0.17 | DNAK_ECOLI (0.48) | 384/1 | 0.81 | DNAK_ECOLI (0.90) |
| Â | GSHB_ECOLI | Glutathione synthetase | 755/1 | 0.30 | AMPM_ECOLI (0.61) | 375/1 | 0.93 | AMPM_ECOLI (0.95) |
| Â | DPO3A_ECOLI | DNA polymerase III subunit alpha | 306/1 | 0.70 | DPO3E_ECOLI (0.73) | 128/1 | 0.11 | DPO3E_ECOLI (0.57) |
| Â | DPO3E_ECOLI | DNA polymerase III subunit epsilon | 357/1 | 0.64 | DPO3A_ECOLI (0.73) | 123/1 | 0.22 | (0.57) max |
| Â | RPOB_ECOLI | DNA-directed RNA polymerase subunit beta | 280/7 | 0.82 | (0.98) max | 126/4 | 0.48 | (0.93) max |
"old" (COMPLEXES) | RPOA_ECOLI | DNA-directed RNA polymerase subunit alpha | 258/6 | 0.81 | (0.80) max | 90/3 | 0.48 | (0.93) max |
| Â | ZNUB_ECOLI | High-affinity zinc uptake system membrane protein znuB | 370/2 | 1.00 | (0.87) max | 129/1 | 0.36 | ZNUC_ECOLI (0.74) |
| Â | ZNUC_ECOLI | Zinc import ATP-binding protein ZnuC | 386/2 | 0.99 | (0.87) max | 123/2 | 0.41 | (0.74) max |
| Â | ZNUA_ECOLI | High-affinity zinc uptake system protein znuA | 395/2 | 0.98 | (0.87) max | 39/1 | 0.79 | ZNUC_ECOLI (0.74) |