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Table 1 Examples of potentially "new" and "old" interacting pairs of proteins whose co-evolution was evaluated using two sets of organisms

From: Selection of organisms for the co-evolution-based study of protein interactions

  Protein Level9(= all) Nearest2
    Tot/+ AUC Interactor (corr) Tot/+ AUC Interactor (corr)
  MINE_ECOLI Cell division topological specificity factor 846/1 0.12 MIND_ECOLI (0.52) 223/1 0.83 MIND_ECOLI (0.60)
"recent"
(BINARY_PHYS)
PABA_ECOLI Para-aminobenzoate synthase glutamine amidotransferase component II 671/1 0.28 PABB_ECOLI (0.49) 106/1 0.96 PABB_ECOLI (0.96)
  DHAS_ECOLI Aspartate-semialdehyde dehydrogenase 760/1 0.17 DNAK_ECOLI (0.48) 384/1 0.81 DNAK_ECOLI (0.90)
  GSHB_ECOLI Glutathione synthetase 755/1 0.30 AMPM_ECOLI (0.61) 375/1 0.93 AMPM_ECOLI (0.95)
  DPO3A_ECOLI DNA polymerase III subunit alpha 306/1 0.70 DPO3E_ECOLI (0.73) 128/1 0.11 DPO3E_ECOLI (0.57)
  DPO3E_ECOLI DNA polymerase III subunit epsilon 357/1 0.64 DPO3A_ECOLI (0.73) 123/1 0.22 (0.57) max
  RPOB_ECOLI DNA-directed RNA polymerase subunit beta 280/7 0.82 (0.98) max 126/4 0.48 (0.93) max
"old"
(COMPLEXES)
RPOA_ECOLI DNA-directed RNA polymerase subunit alpha 258/6 0.81 (0.80) max 90/3 0.48 (0.93) max
  ZNUB_ECOLI High-affinity zinc uptake system membrane protein znuB 370/2 1.00 (0.87) max 129/1 0.36 ZNUC_ECOLI (0.74)
  ZNUC_ECOLI Zinc import ATP-binding protein ZnuC 386/2 0.99 (0.87) max 123/2 0.41 (0.74) max
  ZNUA_ECOLI High-affinity zinc uptake system protein znuA 395/2 0.98 (0.87) max 39/1 0.79 ZNUC_ECOLI (0.74)
  1. The co-evolution between these proteins was evaluated using the "level9" and "nearest2" sets of organisms. The total number of pairs involving each protein for which it was possible to make calculations, as well as the number of positives (+) are indicated. The co-evolutionary score with the interactor is also shown (corr). For the cases for which the list contain more than one positive the score is the highest one (max). Finally, the AUC value for the list of scores is also included.