Genome features of BCP hot-spots in the SCIDX1, CGD, and X-linked ALD trials. Plots (A), (C), and (D) show the median feature density per Mb and the interquartile range of BCP hot-spot regions in comparison to the genome median. In plot B the enrichment of cancer genes was calculated relative to the RefSeq gene numbers in order to control for gene density differences. The LV data sets showed enrichment of (A) RefSeq genes and (C) CpG islands relative to the genome median (indicated by an asterisk *). No other comparisons to the genome median reached significance at the Bonferroni-corrected level. Overlap of interquartile ranges among the LV data sets shows that their BCP hot-spots have similar genomic features.