Figure 1

Schematic showing the relationships between UniProtKB, ProForm, GO, and ProComp. Arrows between ProForm and UniProtKB are xref, those between ProComp and ProForm are has_part, and between ProComp and Gene Ontology the arrows depict is_a relationships. In ProForm each protein form is assigned a unique identifier and is cross-referenced to protein entries in UniProtKB. Protein isoforms and modified forms are described in UniProtKB records, but in contrast to PRO, each protein form is not represented as a separate, uniquely accessioned entity in UniProtKB. For example, for the alpha subunit of IDH in mouse there is a PRO entry for the protein (PR:000025358) and for each of the alpha protein isoforms (PR:000025355 and PR:000025356). In UniProt the IDH alpha subunit and its isoforms are all represented in the same record (UniProt: Q9D6R2). In ProComp, accessioned, species-specific protein complex entities are described using protein entries from ProForm. The protein complexes in ProComp are cross-referenced to species-independent complex representations in the Gene Ontology (GO).