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Table 1 Examples of cross-domain GO term pairs which have a high CAS or PAS

From: Quantification of protein group coherence and pathway assignment using functional association

GO ID 1 Description Domain GO ID 2 Description Domain CAS PAS
GO:0047077 Photinus-luciferin 4-monooxygenase activity MF GO:0008218 Bioluminescence BP 697.12 0.124
GO:0009544 Chloroplast ATP synthase complex CC GO:0009772 photosynthetic electron transport in photosystem II BP 232.37 0.0572
GO:0033592 RNA strand annealing activity MF GO:0000373 Group II intron splicing BP 116.19 0.0367
GO:0034437 Glycoprotein transporter activity MF GO:0010887 negative regulation of cholesterol storage BP 232.37 0
GO:0051636 Gram-negative bacterial cell surface binding MF GO:0015920 lipopolysaccharide transport BP 348.56 0.0195
GO:0047635 alanine-oxo-acid transaminase activity MF GO:0019481 L-alanine catabolic process, by transamination BP 232.37 0.3489
GO:0046812 host cell surface binding MF GO:0019064 viral envelope fusion with host membrane BP 116.18 0.0756
GO:0047558 3-cyanoalanine hydratase activity MF GO:0019499 cyanide metabolic process BP 697.11 0.0653
GO:0047429 nucleoside-triphosphate diphosphatase activity MF GO:0009149 pyrimidine nucleoside triphosphate catabolic process BP 116.18 0
GO:0033328 peroxisome membrane targeting sequence binding MF GO:0045046 protein import into peroxisome membrane BP 199.17 2.690
GO:0031499 TRAMP complex CC GO:0034470 ncRNA processing BP 1.316 4.317
GO:0070531 BRCA1-A complex CC GO:0016579 Protein deubiquitination BP 4.497 5.164
GO:0031252 Cell leading edge CC GO:0070507 regulation of microtubule cytoskeleton organization BP 0.0097 0.0115
GO:0030893 meiotic cohesin complex CC GO:0000819 sister chromatid segregation BP 0.498 0.759
GO:0043566 structure-specific DNA binding MF GO:0033567 DNA replication, Okazaki fragment processing BP 0.178 0.352
GO:0042781 3'-tRNA processing endoribonuclease activity MF GO:0034414 tRNA 3'-trailer cleavage, endonucleolytic BP 232.37 116.186
GO:0000816 nicotinamide riboside kinase activity MF GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway BP 348.55 104.567
GO:0001735 prenylcysteine oxidase activity MF GO:0030328 prenylcysteine catabolic process BP 232.37 22.487
GO:0004121 cystathionine beta-lyase activity MF GO:0019279 methionine biosynthetic process from L-homoserine via cystathionine BP 139.42 15.154
GO:0070635 nicotinamide riboside hydrolase activity MF GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway BP 348.55 27.884
  1. The table is divided into two halves with the first half containing examples of GO term pairs across different domains that have high CAS while the second half has examples with high PAS. For each of the term its description in the GO database and the domain (MF/BP/CC) where it belongs is provided. First five examples in each of the two halves are discussed in detail in the text whereas the latter five examples in each part provide missing process-function links that are detected by high CAS or PAS and are not currently linked using the part-of relationship in GO database.