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Table 4 Results for both datasets using GRLR

From: Multilocus association mapping using generalized ridge logistic regression

Dataset

Chr

Selected Subset of SNPs

Test Statistic

Empirical P-value

heroin addiction

1

{rs1408830, rs965972}

1.26 × 10-07

0.027

AMD HK

10

{rs2736911, rs10490924, rs763720}

1.32 × 10-11

0.000

  1. Analysis results for two published datasets using our GRLR method. Genomic search regions are constructed based on the SNPs whose single-locus p-values are no larger than a fixed threshold 0.05 for the heroin addiction data, and 0.01 for the AMD Hong Kong data; the truncation threshold within each search region is set to 0.05; the maximal length on each side of the central SNP is set to 10; the tuning parameter λ in GRLR model is set to 1.0. Empirical p-values are derived from 1000 permutations.
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BMC Bioinformatics

ISSN: 1471-2105

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