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Table 3 Site-Directed Mutants of novel NNRTI resistance associated mutations 139R, 219D and 219H in combination with 103N+181C and SDM 181G

From: Cross-validated stepwise regression for identification of novel non-nucleoside reverse transcriptase inhibitor resistance associated mutations

SDM drug 3 measurements (Fold Changea)
139R NVP 7.3 7.3 6.4
  EFV 1.5 2.2 2.7
  ETR 1.2 1.2 1.0
219D NVP 3.7 3.8 1.4
  EFV 1.3 2.2 1.3
  ETR 1.1 2.0 0.4
219H NVP 2.1 2.2 1.3
  EFV 1.1 1.0 1.8
  ETR 1.8 1.7 1.1
103N NVP > 51.7 > 54.2 35.4
  EFV 19.5 15.1 12.5
  ETR 1.1 0.9 0.6
103N+181C NVP > 85.9 > 85.9 > 85.9
  EFV 28.4 23.1 38.7
  ETR 4.2 1.7 3.2
139R+103N+181C NVP > 22.7 > 21.8 > 22.7
  EFV 60.2 77.0 61.2
  ETR 7.0 7.4 5.6
219D+103N+181C NVP > 79.6 > 79.6 > 76.7
  EFV 116.6 72.9 48.6
  ETR 15.5 20.2 21.4
219H+103N+181C NVP > 79.6 > 79.6 > 79.6
  EFV 92.6 23.7 49.0
  ETR 14.5 16.1 11.6
181G NVP 30.1 38.3 > 37.2
  EFV 1.6 1.3 1.1
  ETR 1.5 0.9 1.2
  1. a > Biological Cut-Off (BCO) in bold, ≤ BCO in italic; BCO for NVP is 6.0, BCO for EFV is 3.3 and BCO for ETR is 3.2.