Table 3 Site-Directed Mutants of novel NNRTI resistance associated mutations 139R, 219D and 219H in combination with 103N+181C and SDM 181G
SDM | drug | 3 measurements (Fold Changea) | ||
|---|---|---|---|---|
139R | NVP | 7.3 | 7.3 | 6.4 |
| Â | EFV | 1.5 | 2.2 | 2.7 |
| Â | ETR | 1.2 | 1.2 | 1.0 |
219D | NVP | 3.7 | 3.8 | 1.4 |
| Â | EFV | 1.3 | 2.2 | 1.3 |
| Â | ETR | 1.1 | 2.0 | 0.4 |
219H | NVP | 2.1 | 2.2 | 1.3 |
| Â | EFV | 1.1 | 1.0 | 1.8 |
| Â | ETR | 1.8 | 1.7 | 1.1 |
103N | NVP | > 51.7 | > 54.2 | 35.4 |
| Â | EFV | 19.5 | 15.1 | 12.5 |
| Â | ETR | 1.1 | 0.9 | 0.6 |
103N+181C | NVP | > 85.9 | > 85.9 | > 85.9 |
| Â | EFV | 28.4 | 23.1 | 38.7 |
| Â | ETR | 4.2 | 1.7 | 3.2 |
139R+103N+181C | NVP | > 22.7 | > 21.8 | > 22.7 |
| Â | EFV | 60.2 | 77.0 | 61.2 |
| Â | ETR | 7.0 | 7.4 | 5.6 |
219D+103N+181C | NVP | > 79.6 | > 79.6 | > 76.7 |
| Â | EFV | 116.6 | 72.9 | 48.6 |
| Â | ETR | 15.5 | 20.2 | 21.4 |
219H+103N+181C | NVP | > 79.6 | > 79.6 | > 79.6 |
| Â | EFV | 92.6 | 23.7 | 49.0 |
| Â | ETR | 14.5 | 16.1 | 11.6 |
181G | NVP | 30.1 | 38.3 | > 37.2 |
| Â | EFV | 1.6 | 1.3 | 1.1 |
| Â | ETR | 1.5 | 0.9 | 1.2 |