Figure 3

Canonical expansion. A search for first order interactors of Entrez GeneID 51564 (HDAC7) with canonical expansion of the search term returns interactors for two isoforms of HDAC7 (blue nodes). Searching without canonical expansion would only return interactors for the node labelled HDAC7 (corresponding to RefSeq: NP_056216) because the sequence for HDAC7_HUMAN (UniProt: Q8WUI4) was not among the splice-isoforms in the Entrez Gene record at the time of iRefIndex build 8.0. However, the Q8WUI4-5 splice isoform was identical to NP_056216 so both interactors were mapped to the same canonical group. Manual inspection of the source records found no evidence for the involvement of any particular splice isoform of HDAC7 so the interaction data for both forms shown can be merged safely.