Enhanced peptide quantification using spectral count clustering and cluster abundance

BMC Bioinformatics

Table 5 Validation for clustering result using the false clustering rate (FCR)

In order to validate the clustering results, we propose a new measure to estimate the clustering error rate using the spectral retention time (RT) information. We computed the false clustering rate (FCR) for various values of threshold Δ, as summarized. We also calculated FCR to determine the cut-off value of correlation coefficient for spectral clustering. We computed FCR for the various values of the given ρ, as summarized. We chose ρ = 0.6 which yielded FCR close to 0.05.

ISSN: 1471-2105