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Table 4 Gene Set Enrichment Analysis to identify functional groups from CDEP identified genes.

From: Consistent Differential Expression Pattern (CDEP) on microarray to identify genes related to metastatic behavior

Functions (source) Annotated genes FDR
ECM-receptor interaction (KEGG) COL4A2,COL4A1,TNC,COL3A1,COL5A2,COL5A1,COL6A3,COL1A2,COL1A1,LAMB1,COL11A1,THBS2,
FN1,SPP1
1.84 × 10-8
Focal adhesion (KEGG) CAV1,COL4A2,COL4A1,TNC,COL3A1,COL5A2,COL5A1,MYL9,VEGFC,VEGFA,COL6A3,COL1A2,
COL1A1,LAMB1,THBS2,COL11A1,FN1,SPP1
2.02 × 10-7
Blood vessel development
(GO)
PLAT,CAV1,IL8,COL3A1,COL15A1,COL5A1,VEGFC,APOB,APOE,CTGF,VEGFA,COL1A2,SEMA3C,LOX,COL1A1,CYR61 1.10 × 10-5
Immune response (GO) CXCL1,POU2AF1,CCL2,BST2,CXCL3,IGJ,CXCL2,CXCL9,IL32,IFI44L,CCL5,CXCL11,HLA-DMA,
HLA-DQA1,PSMB8,CXCL10,PSMB9,CXCL13,TAP1,DEFB1,GBP1
2.06 × 10-6
Inflammatory response (GO) CXCL1,CCL2,NMI,CXCL3,CXCL2,CXCL9,ANXA1,IDO1,CXCL11,CCL5,CXCL10,FOS,SAA2,CXCL13 5.95 × 10-5
  1. The functional enrichment for the genes identified as consistently differentially expressed between primary and metastatic cancers.