Figure 7
From: Multiple-input multiple-output causal strategies for gene selection
Most enriched GO terms with respect to λ according to a pre-ranked gene set enrichment analysis (GSEA): (A) GO terms enriched in the conventional ranking and having a high degree of causality for tumorigenesis; (B) GO terms increasingly enriched with respect to larger λ, suggesting they are putative causes for tumorigenesis; (C) GO terms decreasingly enriched with respect to larger λ, suggesting they are putative effects for tumorigenesis. The normalized enrichment score (NES) depends on the genome-ranking of the genes, which in turn depends on λ. Larger the NES of a GO term, stronger the association of this gene set with survival; the sign of NES reflects the direction of association of the GO term with survival, a positive score meaning that over-expression of the genes implies worst survival and inversely.