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Figure 3 | BMC Bioinformatics

Figure 3

From: Integrative set enrichment testing for multiple omics platforms

Figure 3

Heterogeneous simulation results ( N G S =20, N M S =4). 1000 genes and 200 metabolites generated for 30 samples. Genes (G), Metabolites (M), or both (G + M) are differentially expressed within the set with probability according to the enrichment percentage listed in the black boxes at the top of the plot. Each trio of columns, from left to right, represents no correlation (ρ GG = ρ MM = ρ MG = 0), correlation within element only (ρ GG = ρ MM = 0.20, and ρ MG = 0), and correlation within and between elements (ρ GG = ρ MM = 0.20, and ρ MG = 0.10). Sets 25,..., 29 were chosen randomly. The symbols represent the frequency of rejecting the null hypothesis in 100 simulated datasets. [Blue square, univariate gene; Purple circle, univariate metaboltie; Orange triangle, concatenation; Black star, Fisher's method; Red diamond, multivariate extension]

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