TY - JOUR AU - Tataru, Paula AU - Hobolth, Asger PY - 2011 DA - 2011/12/05 TI - Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains JO - BMC Bioinformatics SP - 465 VL - 12 IS - 1 AB - Continuous time Markov chains (CTMCs) is a widely used model for describing the evolution of DNA sequences on the nucleotide, amino acid or codon level. The sufficient statistics for CTMCs are the time spent in a state and the number of changes between any two states. In applications past evolutionary events (exact times and types of changes) are unaccessible and the past must be inferred from DNA sequence data observed in the present. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-12-465 DO - 10.1186/1471-2105-12-465 ID - Tataru2011 ER -