Table 8 The statistical significance (i.e. p-values) of SP and TC alignment score differences between MSACompro and the other tools on three benchmark data sets.

Clustalw/SP score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

Clustalw/TC score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

DIALIGN-TX/SP score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

DIALIGN-TX/TC score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

FSA/SP score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

FSA/TC score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

MAFFT/SP score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

MAFFT/TC score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

MSAProbs/SP score

2.931 × 10^-3

< 2.2 × 10^-16

< 2.2 × 10^-16

MSAProbs/TC score

0.4839

< 2.2 × 10^-16

< 2.2 × 10^-16

MUSCLE/SP score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

MUSCLE/TC score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

Opal/SP score

3.384 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

Opal/TC score

2.15 × 10^-14

< 2.2 × 10^-16

< 2.2 × 10^-16

POA/SP score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

POA/TC score

< 2.2 × 10^-16

< 2.2 × 10^-16

< 2.2 × 10^-16

Probalign/SP score

2.87 × 10^-6

< 2.2 × 10^-16

< 2.2 × 10^-16

Probalign/TC score

4.158 × 10^-3

< 2.2 × 10^-16

< 2.2 × 10^-16

ProbCons/SP score

2.16 × 10^-15

< 2.2 × 10^-16

< 2.2 × 10^-16

ProbCons/TC score

6.817 × 10^-7

< 2.2 × 10^-16

< 2.2 × 10^-16

T-coffee/SP score

1.225 × 10^-14

< 2.2 × 10^-16

< 2.2 × 10^-16

T-coffee/TC score

4.503 × 10^-8

< 2.2 × 10^-16

< 2.2 × 10^-16

MUMMALS/SP score

6.191 × 10^-10

< 2.2 × 10^-16

2.446 × 10^-15

MUMMALS/TC score

8.104 × 10^-5

< 2.2 × 10^-16

1.265 × 10^-12

PROMALS/SP score

0.0116 (-)

< 2.2 × 10^-16 (-)

0.0186 (-)

PROMALS/TC score

0.529

< 2.2 × 10^-16 (-)

0.0274 (-)

PROMALS3D/SP score

0.0149 (-)

< 2.2 × 10^-16 (-)

< 2.2 × 10^-16 (-)

PROMALS3D/TC score

0.0078 (-)

< 2.2 × 10^-16 (-)

< 2.2 × 10^-16 (-)