Figure 5

Computational flow in the search of logic triplets of genes. 182 representative bacteria genomes were selected from the 770 bacteria genomes available in Roundup [14, 15], and orthologs were identified using the RSD (Reciprocal Smallest Distance) algorithm [15]. The final matrix contained 13,673 gene profiles. In the computation of the logic triplets, p' _ijk , the balanced profile was created to give equal weight on the four scenarios of coevolution between genes a and b. ΔU was taken as the significance of a triplet; a value greater than 0.3 was deemed significant. The percentage of triplets where the three genes share common GO terms was used to measure the accuracy of the prediction.