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Figure 2 | BMC Bioinformatics

Figure 2

From: Normalizing for individual cell population context in the analysis of high-content cellular screens

Figure 2

Results of the population context and technical feature computations. (a) Explained standard deviation of cell population context and technical features with respect to single-cell viral infection efficiency. Shown are the ratios of the between-bin standard deviation to the average within-bin standard deviation, as a measure of the fraction of the variation explained by the cell population or technical feature under consideration. Blue: Hepatitis C virus (HCV) screen, red: Dengue virus (DENV) screen. While overall variability is larger for DENV, the relative effect of individual features is comparable between both viruses under consideration. Importantly, a clear effect of cell population context on viral infection is discernible. (b) Percentage of explained standard deviation for cell context features for HCV and DENV, relative to the total variability due to cell population context. (c) Mean and standard deviation of the two population context features which are most important, namely Cell Size and Cell number of the two screens in the twenty individual bins.

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