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Figure 3 | BMC Bioinformatics

Figure 3

From: Partition decoupling for multi-gene analysis of gene expression profiling data

Figure 3

PDM results for radiation response data. In (a) and (b) we see scatter plots of each sample's Fiedler vector value along with the resulting clustering (indicated by color) for the first (a) and second (b) PDM layers. A Gaussian mixture fit to the density (left panel) of the Fiedler vector is used to assess the number of clusters, and the resulting cluster assignment for each sample is indicated by color. Exposure is indicated by shape ("M"-mock; "U"-UV; "I"-IR), with phenotypes (healthy, skin cancer, radiation insensitive, radiation sensitive) grouped together along the x-axis. In (a), it can be seen that the cluster assignment correlates with exposure, while in (b), cluster assignment correlates with radiation sensitivity. In (c), points are placed in the grid according to cluster assignment from layers 1 and 2 along the x and y axes; it can be seen that the UV-and IR- exposed high-sensitivity samples differ both from the mock-exposed high-sensitivity samples as well as the UV- and IR- exposed control samples.

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