Table 3 Information stored in Dr. PIAS.

Structural information

   Tertiary structures

[22–24]

   Pockets on PPI interface

[25]

Volume

[6, 25]

Accessible surface area

[6, 25]

Compactness

[6]

Planarity

[6]

Narrowness

[6]

Curvature

[26]

Roughness

[26]

Amino acid composition

[6, 24, 25, 27]

   Domains

[28, 29]

   Disordered regions

[37]

   Amino acid sequence motifs

[38, 39]

Drug/chemical information

   FDA-approved drugs

[40]

   Chemicals associated with interacting proteins

[41]

Functional information

   Human diseases in OMIM

[42]

   Number of interacting proteins in PPI network

[6]

   Biological pathways

[43, 44]

   GO terms and identity scores of GO terms

[6, 45]

   Gene expression profiles and similarity scores of profiles

[6, 46]

   Paralogs

[43, 47]