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Table 3 Information stored in Dr. PIAS.

From: Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions

Information Source(s) or program(s) used
Structural information  
   Tertiary structures [2224]
   Pockets on PPI interface [25]
Volume [6, 25]
Accessible surface area [6, 25]
Compactness [6]
Planarity [6]
Narrowness [6]
Curvature [26]
Roughness [26]
Amino acid composition [6, 24, 25, 27]
   Domains [28, 29]
   Disordered regions [37]
   Amino acid sequence motifs [38, 39]
Drug/chemical information  
   FDA-approved drugs [40]
   Chemicals associated with interacting proteins [41]
Functional information  
   Human diseases in OMIM [42]
   Number of interacting proteins in PPI network [6]
   Biological pathways [43, 44]
   GO terms and identity scores of GO terms [6, 45]
   Gene expression profiles and similarity scores of profiles [6, 46]
   Paralogs [43, 47]