From: Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions
PPI | Druggability score | |||
---|---|---|---|---|
 | Structural attributes | Drug/chemical attributes | Functional attributes | All attributes |
CREBBP/TP53 | 0.9747 | 0.2234 | 0.9682 | 0.9507 |
E2F1/RB1 | 0.6162 | 0.4677 | 0.9922 | 0.9402 |
E2F2/RB1 | 0.8452 | 0.4677 | 0.9964 | 0.9000 |
EGFR/TGFA | 0.6832 | 0.7028 | 0.9957 | 0.9393 |
EP300/TP53 | 0.9747 | 0.2234 | 0.9214 | 0.9454 |
GRB2/GRB2 | 0.9327 | 0.2356 | 0.9838 | 0.9058 |
GRB2/VAV1 | 0.7431 | 0.2234 | 0.9978 | 0.9662 |
HRAS/RAF1 | 0.5453 | 0.3029 | 0.9973 | 0.9140 |
HRAS/RALGDS | 0.9320 | 0.2234 | 0.9891 | 0.9152 |
HRAS/RASA1 | 0.7267 | 0.2234 | 0.9988 | 0.9459 |
HRAS/SOS2 | 0.8991 | 0.2234 | 0.9911 | 0.9293 |
NFKB1/NFKBIA | 0.8607 | 0.8146 | 0.9993 | 0.9343 |
NFKB1/RELB | 0.5218 | 0.8146 | 0.9868 | 0.9195 |
RAF1/RAP1A | 0.8070 | 0.4380 | 0.9937 | 0.9154 |
TP53/TP53BP2 | 0.2102 | 0.2234 | 0.3776 | 0.9274 |
XIAP/CASP3 | 0.5897 | 0.3679 | 0.9998 | 0.9219 |
XIAP/CASP9 | 0.7910 | 0.2277 | 0.9954 | 0.9468 |