Skip to main content

Table 4 List of PPIs assessed as potentially druggable for lung cancer.

From: Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions

PPI

Druggability score

 

Structural attributes

Drug/chemical attributes

Functional attributes

All attributes

CREBBP/TP53

0.9747

0.2234

0.9682

0.9507

E2F1/RB1

0.6162

0.4677

0.9922

0.9402

E2F2/RB1

0.8452

0.4677

0.9964

0.9000

EGFR/TGFA

0.6832

0.7028

0.9957

0.9393

EP300/TP53

0.9747

0.2234

0.9214

0.9454

GRB2/GRB2

0.9327

0.2356

0.9838

0.9058

GRB2/VAV1

0.7431

0.2234

0.9978

0.9662

HRAS/RAF1

0.5453

0.3029

0.9973

0.9140

HRAS/RALGDS

0.9320

0.2234

0.9891

0.9152

HRAS/RASA1

0.7267

0.2234

0.9988

0.9459

HRAS/SOS2

0.8991

0.2234

0.9911

0.9293

NFKB1/NFKBIA

0.8607

0.8146

0.9993

0.9343

NFKB1/RELB

0.5218

0.8146

0.9868

0.9195

RAF1/RAP1A

0.8070

0.4380

0.9937

0.9154

TP53/TP53BP2

0.2102

0.2234

0.3776

0.9274

XIAP/CASP3

0.5897

0.3679

0.9998

0.9219

XIAP/CASP9

0.7910

0.2277

0.9954

0.9468

  1. From the 116 PPIs searched in Dr. PIAS using the keywords and options, the PPIs having a druggability score of ≥0.9 in the 'All attributes' column are listed.