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Table 4 List of PPIs assessed as potentially druggable for lung cancer.

From: Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions

PPI Druggability score
  Structural attributes Drug/chemical attributes Functional attributes All attributes
CREBBP/TP53 0.9747 0.2234 0.9682 0.9507
E2F1/RB1 0.6162 0.4677 0.9922 0.9402
E2F2/RB1 0.8452 0.4677 0.9964 0.9000
EGFR/TGFA 0.6832 0.7028 0.9957 0.9393
EP300/TP53 0.9747 0.2234 0.9214 0.9454
GRB2/GRB2 0.9327 0.2356 0.9838 0.9058
GRB2/VAV1 0.7431 0.2234 0.9978 0.9662
HRAS/RAF1 0.5453 0.3029 0.9973 0.9140
HRAS/RALGDS 0.9320 0.2234 0.9891 0.9152
HRAS/RASA1 0.7267 0.2234 0.9988 0.9459
HRAS/SOS2 0.8991 0.2234 0.9911 0.9293
NFKB1/NFKBIA 0.8607 0.8146 0.9993 0.9343
NFKB1/RELB 0.5218 0.8146 0.9868 0.9195
RAF1/RAP1A 0.8070 0.4380 0.9937 0.9154
TP53/TP53BP2 0.2102 0.2234 0.3776 0.9274
XIAP/CASP3 0.5897 0.3679 0.9998 0.9219
XIAP/CASP9 0.7910 0.2277 0.9954 0.9468
  1. From the 116 PPIs searched in Dr. PIAS using the keywords and options, the PPIs having a druggability score of ≥0.9 in the 'All attributes' column are listed.