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Figure 3 | BMC Bioinformatics

Figure 3

From: A Computational Framework for Proteome-Wide Pursuit and Prediction of Metalloproteins using ICP-MS and MS/MS Data

Figure 3

Protein selection using GMPA score significance curve criterion. Scatterplots (per metal) of the GMPA scores versus number of fraction occurrences for all proteins. The green/orange lines are exponential "significance" curves (plotted on a logarithmic scale) and proteins below are considered significant and selected for clustering (green regions and cyan points). The Ni significance curve (green) was based on occurrences of known Ni-proteins (red points) and the Mo significance curve (orange) was extrapolated from the relationships between the significance curves and exponential regression curves (through all points-the black lines) on average across all metals with known metalloproteins. Typically, this step removes an additional 20-35 proteins beyond what would be removed using the regression curves themselves.

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