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Figure 3 | BMC Bioinformatics

Figure 3

From: MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model

Figure 3

Output of "miRNA regulation". (A) Result of the prediction of target genes for the miRNA 200 family (cluster of down-regulated hsa-mir-200a, hsa-mir-200b, hsa-mir-429) with medium stringency criteria (miRBase score ≥ 16 and p-value ≤ 0.05, microRNA.org score ≥ 150, at least two miRNAs per gene). The output list was filtered with a list of 132 up-regulated genes. The 20 predicted target genes presented in the table (lower panel) were sorted by the Fisher test p-value. Information can be obtained for each target gene, including its miRNA regulators and unified prediction scores (panels for the first gene is shown). (B) Generated regulation graph with all input miRNAs shown as down-regulated (diamonds in green) and predicted target genes shown as up-regulated (ellipses and square in red). Edges represent regulations, and the gray canonical color code corresponds to the quality score.

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BMC Bioinformatics

ISSN: 1471-2105

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