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Table 3 Power comparison for MAF = 0.25 (K = 0.1, α = 0.05, m = 5 × 105)

From: Robust joint analysis allowing for model uncertainty in two-stage genetic association studies

 

Ï€

γ

ALLEJ

CATAJ

MERTJ

MAX3J

Recessive Model

0.5

0.0001

0.075

0.066

0.220

0.517

r = s = 5000

 

0.0002

0.083

0.073

0.242

0.546

λ1 = 1, λ2 = 1.5

0.4

0.0001

0.053

0.047

0.154

0.365

  

0.0002

0.062

0.055

0.180

0.408

 

0.3

0.0001

0.031

0.028

0.087

0.197

  

0.0002

0.039

0.035

0.110

0.254

Additive Model

0.5

0.0001

0.835

0.846

0.782

0.799

r = s = 2000

 

0.0002

0.868

0.878

0.820

0.838

λ1 = 1.4, λ2 = 1.8

0.4

0.0001

0.687

0.700

0.625

0.639

  

0.0002

0.742

0.754

0.683

0.700

 

0.3

0.0001

0.462

0.474

0.405

0.413

  

0.0002

0.530

0.542

0.472

0.476

Dominant Model

0.5

0.0001

0.717

0.757

0.511

0.826

r = s = 2000

 

0.0002

0.758

0.796

0.551

0.853

λ1 = λ2 = 1.5

0.4

0.0001

0.557

0.597

0.375

0.651

  

0.0002

0.617

0.656

0.427

0.726

 

0.3

0.0001

0.350

0.382

0.221

0.425

  

0.0002

0.413

0.447

0.270

0.495