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Figure 3 | BMC Bioinformatics

Figure 3

From: Statistical Test of Expression Pattern (STEPath): a new strategy to integrate gene expression data with genomic information in individual and meta-analysis studies

Figure 3

LGMDs analysis workflow cartoon. 1) Independent application of STEPath to the N considered datasets (e.g., for analysis of LGMDs LGMD2A, LGMD2B, LGMD2I from GSE3307 and nLGMD2A from GSE11681). 2) Selection of the Main Gene set Signature (MGS) from GSE3307 dataset. Selection was performed by identifying gene sets having an expression value upper or lower (for up- or down-regulated regions, respectively) than average of expression of all significant gene sets. 3) Extraction of the MGS expression values from all datasets considered. 4) Matrix construction. 5) Normalization and cluster analysis.

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