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Table 1 Selectivity metrics calculated for the Ambit kinase profiling dataset

From: A theoretical entropy score as a single value to express inhibitor selectivity

code Gini S3uM S10x Pmax Ka-Gini entropies
PI-103 0.41 0.00 0.00 0.97 0.99 0.05
CI-1033 0.72 0.15 0.00 0.88 0.99 0.17
GW-2580 0.54 0.01 0.00 0.92 0.99 0.26
VX-745 0.51 0.03 0.00 0.92 0.99 0.28
Gefitinib 0.65 0.07 0.00 0.89 0.99 0.44
Lapatinib 0.57 0.01 0.00 0.70 0.99 0.70
Erlotinib 0.75 0.15 0.00 0.67 0.99 0.88
EKB-569 0.78 0.18 0.00 0.67 0.99 0.89
Imatinib 0.79 0.07 0.02 0.65 0.99 1.05
CP-724714 0.49 0.02 0.01 0.33 0.99 1.10
CP-690550 0.66 0.03 0.01 0.50 0.99 1.11
BIRB-796 0.81 0.16 0.00 0.47 0.99 1.15
PTK-787 0.71 0.03 0.02 0.44 0.98 1.54
SB-431542 0.42 0.02 0.01 0.14 0.98 1.56
MLN-518 0.74 0.06 0.01 0.26 0.98 1.58
LY-333531 0.76 0.16 0.01 0.42 0.98 1.68
CHIR-258 0.76 0.33 0.01 0.44 0.97 1.80
AZD1152HQPA 0.78 0.10 0.02 0.34 0.98 1.91
ABT-869 0.82 0.16 0.01 0.32 0.98 1.93
MLN-8054 0.75 0.13 0.01 0.36 0.97 1.95
Roscovitine 0.33 0.03 0.03 0.12 0.98 2.02
SU-14813 0.70 0.51 0.02 0.18 0.97 2.04
Sunitinib 0.67 0.57 0.02 0.11 0.97 2.05
GW-786034 0.80 0.21 0.02 0.33 0.97 2.06
SB-202190 0.76 0.09 0.02 0.35 0.97 2.08
Sorafenib 0.82 0.18 0.10 0.46 0.97 2.15
SB-203580 0.77 0.10 0.02 0.24 0.97 2.26
AMG-706 0.82 0.09 0.04 0.22 0.97 2.36
SNS-032 0.80 0.13 0.06 0.30 0.97 2.44
CHIR265 0.74 0.13 0.12 0.36 0.96 2.47
Flavopiridol 0.77 0.19 0.17 0.42 0.95 2.50
AST-487 0.73 0.45 0.04 0.11 0.95 2.74
ZD-6474 0.79 0.27 0.26 0.28 0.94 2.88
Staurosporine 0.35 0.87 0.50 0.02 0.93 2.91
VX-680 0.76 0.38 0.03 0.15 0.93 3.09
Dasatinib 0.79 0.28 0.10 0.03 0.93 3.21
PKC-412 0.71 0.47 0.08 0.10 0.88 3.72
JNJ-7706621 0.74 0.37 0.08 0.10 0.87 3.73
  1. Values for various selectivity metrics. In the Additional file 1, this table is extended with compound rank ordering and rank differences, and colour coded for clarity.