Figure 3
From: A genetic algorithm-based boolean delay model of intracellular signal transduction in inflammation
LPS/IL1/TNF → NF-κB network after simplification. LPS/IL1/TNF induced network after simplification. In the network, TNF, IL-1 and LPS are inputs. A-20, IL-1 and TNF are three key feedbacks. NF-κB, IKK and IκBα are observable outputs which can be detect from experiment. An edge between nodes indicates interaction. Arrow implies activation blunted line denotes inhibition. Within the red box is the kernel pathway of between IKK, IkBa and NFkB.