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Table 2 UniProt accession numbers of selected proteins in the top 20 conserved pathways of size L = 64 with protein names and the associated top ontology keywords and GO terms listed by the UniProt database [42].

From: Comparative analysis of protein interaction networks reveals that conserved pathways are susceptible to HIV-1 interception

UniProt IDs Protein names Gene Ontology terms
P04637 Cellular tumor antigen p53 apoptosis; host-virus interaction; DNA damage response; protein tetramerization
P17612 cAMP-dependent protein kinase catalytic subunit α hormone-mediated signaling pathway; intracellular protein kinase cascade
P28482 Mitogen-activated protein kinase 1 Ras protein signal transduction; cell cycle; transcription; interspecies interaction between organisms; chemotaxis; synaptic transmission
P27361 Mitogen-activated protein kinase 3 Ras protein signal transduction; interspecies interaction between organisms
P05412 Transcription factor AP-1 SMAD protein signal transduction; positive regulation by host of viral transcription; transforming growth factor (TGF) β receptor signaling pathway
P06241 Tyrosine-protein kinase Fyn T cell receptor signaling pathway; interspecies interaction between organisms
P06493 Cell division protein kinase 1 anti-apoptosis; cell division; mitosis
Q15796 Mothers against decapentaplegic homolog 2 SMAD protein complex assembly; intracellular signaling pathway; palate development; transcription; TGF β receptor signaling pathway
P06400 Retinoblastoma-associated protein Cell cycle; Host-virus interaction; androgen receptor signaling pathway; myoblast differentiation
P04049 RAF proto-oncogene serine/ threonine-protein kinase Ras protein signal transduction; cell proliferation; protein amino acid phosphorylation
O14512 Suppressor of cytokine signaling 7 Ubl conjugation pathway; regulation of growth; negative regulation of signal transduction
P10721 Mast/stem cell growth factor receptor male gonad development; transmembrane receptor protein tyrosine; kinase signaling pathway
P15884 Transcription factor 4 cerebral cortex development; regulation of smooth muscle cell proliferation; transcription
P16410 Cytotoxic T-lymphocyte protein 4 immune response; negative regulation of regulatory T cell differentiation
P29597 Non-receptor tyrosine-protein kinase TYK2 intracellular protein kinase cascade; peptidyl-tyrosine phosphorylation
Q13480 GRB2-associated-binding protein 1 cell proliferation; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway
Q15503 Son of sevenless homolog 2 apoptosis; regulation of Rho protein ; signal transduction; small GTPase mediated signal transduction
Q96TE0 Cdk inhibitor p27KIP1 cell cycle arrest
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BMC Bioinformatics

ISSN: 1471-2105

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