Table 2 UniProt accession numbers of selected proteins in the top 20 conserved pathways of size L = 64 with protein names and the associated top ontology keywords and GO terms listed by the UniProt database [42].
UniProt IDs | Protein names | Gene Ontology terms |
|---|---|---|
P04637 | Cellular tumor antigen p53 | apoptosis; host-virus interaction; DNA damage response; protein tetramerization |
P17612 | cAMP-dependent protein kinase catalytic subunit α | hormone-mediated signaling pathway; intracellular protein kinase cascade |
P28482 | Mitogen-activated protein kinase 1 | Ras protein signal transduction; cell cycle; transcription; interspecies interaction between organisms; chemotaxis; synaptic transmission |
P27361 | Mitogen-activated protein kinase 3 | Ras protein signal transduction; interspecies interaction between organisms |
P05412 | Transcription factor AP-1 | SMAD protein signal transduction; positive regulation by host of viral transcription; transforming growth factor (TGF) β receptor signaling pathway |
P06241 | Tyrosine-protein kinase Fyn | T cell receptor signaling pathway; interspecies interaction between organisms |
P06493 | Cell division protein kinase 1 | anti-apoptosis; cell division; mitosis |
Q15796 | Mothers against decapentaplegic homolog 2 | SMAD protein complex assembly; intracellular signaling pathway; palate development; transcription; TGF β receptor signaling pathway |
P06400 | Retinoblastoma-associated protein | Cell cycle; Host-virus interaction; androgen receptor signaling pathway; myoblast differentiation |
P04049 | RAF proto-oncogene serine/ threonine-protein kinase | Ras protein signal transduction; cell proliferation; protein amino acid phosphorylation |
O14512 | Suppressor of cytokine signaling 7 | Ubl conjugation pathway; regulation of growth; negative regulation of signal transduction |
P10721 | Mast/stem cell growth factor receptor | male gonad development; transmembrane receptor protein tyrosine; kinase signaling pathway |
P15884 | Transcription factor 4 | cerebral cortex development; regulation of smooth muscle cell proliferation; transcription |
P16410 | Cytotoxic T-lymphocyte protein 4 | immune response; negative regulation of regulatory T cell differentiation |
P29597 | Non-receptor tyrosine-protein kinase TYK2 | intracellular protein kinase cascade; peptidyl-tyrosine phosphorylation |
Q13480 | GRB2-associated-binding protein 1 | cell proliferation; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway |
Q15503 | Son of sevenless homolog 2 | apoptosis; regulation of Rho protein ; signal transduction; small GTPase mediated signal transduction |
Q96TE0 | Cdk inhibitor p27KIP1 | cell cycle arrest |