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Figure 5 | BMC Bioinformatics

Figure 5

From: The choice of null distributions for detecting gene-gene interactions in genome-wide association studies

Figure 5

Null distributions obtained using the permutation test. We conduct B = 500 permutations for the AMD data set, as described in the method section. The P-values obtained by the permutation test for models M1, M2, M3, M4 are 0.0040, 0.1180, 0.2880 and 0.1480, respectively. Only model M1 is significant. The claim of the significance of the high order interaction (rs1535891, rs2828151, rs404569, rs380390) based on Model M4 in Table 2 is inappropriate.

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BMC Bioinformatics

ISSN: 1471-2105

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