Case |
BB
|
Bb
|
bb
| Control |
BB
|
Bb
|
bb
| MDR table | Case | Control |
---|
AA
| 179 | 119 |
18
|
AA
| 199 | 126 |
15
| Â | Â | Â |
Aa
|
315
|
173
|
26
|
Aa
|
306
|
164
|
17
| Low-risk | 399 | 443 |
aa
| 101 | 59 |
10
|
aa
| 118 |
49
|
6
| High-risk |
601
|
557
|
- Suppose the threshold of the odds ratio in MDR is specified to be Ï„
OR
= 1. Then the 2 × 2 contingency table is obtained by MDR in the following way: For the cells whose odd-ratio is higher than τ
OR
will be considered as high-risk. For case genotypes, the bold numbers indicate these genotypes are considered as high-risk. Their summation equals to 601 as shown in bold font in the MDR table. For control genotypes, the italic numbers also indicate these genotypes are considered as high-risk. Their summation equals to 557 as shown in italic font in the MDR table. For the low-risk cells, this is done in the same way. Statistical tests can be conducted based on the 2 × 2 contingency table: χ2 = 3.9711 for the Pearson χ2 test and χ2 = 3.9726 for the likelihood ratio test.