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Table 3 Fischer’s randomization test results of the pharmacophore hypothesis Hypo 1.

From: Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies

Validation no. Total cost Fixed cost RMSD Correlation
Original hypothesis
Hypo1 81.24 74.770 0.804 0.977
Randomization results
Trial1 116.69 66.395 2.232 0.811
Trial2 133.35 69.600 2.496 0.756
Trial3 124.05 68.126 2.372 0.783
Trial4 189.35 62.993 3.500 0.397
Trial5 171.63 68.169 3.211 0.539
Trial6 158.05 63.578 3.074 0.591
Trial7 116.78 64.678 2.191 0.821
Trial8 135.62 68.457 2.580 0.736
Trial9 140.83 69.702 2.667 0.714
Trial10 172.23 64.740 3.257 0.520