Skip to main content

Table 4 Statistical parameters of GH score validation for Hypo 1.

From: Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies

S. No Parameters Results
1 Total molecules in database (D) 453
2 Total no. of actives in database (A) 206
3 Total hits (Ht) 230
4 Active hits (Ha) 197
5 % Yield of actives [(Ha/Ht) X 100] 85.65
6 % Ratio of actives [(Ha/A) X 100] 95.63
7 Enrichment factor (E) [(Ha X D)/(Ht X A)] 1.88
8 False negatives [A - Ha] 9
9 False positives [Ht - Ha] 33
10 Goodness of hit (GH)* 0.76
  1. *[(Ha/4HtA)(3A + Ht) X (1 – (Ht – Ha)/(D –A))]; GH score of 0.6-0.8 indicates a very good model.