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Table 1 Analysis of factors and their value sets of hypothesis and the results of statistical test (by Fisher’s exact test ) for the TMA data stored in Xperanto-RDF

From: Semantically enabled and statistically supported biological hypothesis testing with tissue microarray databases

Hypothesis Shared property among samples Classifier Dependent property Number of samples (cores) /slides/experiments found in Xperanto-RDF P value
Reduced expression of Apaf-1 in colorectal carcinoma correlates with high-grade phenotype [10]. Colon cancer Apaf-1 intensity
(0 vs. 1-3)
Grade
(High vs. Low-grade)
55/5/3 < 0.0001
In gastric cancer, Apaf-1 expression is associated with high grade malignancy. Stomach caner Apaf-1 intensity
(0 vs. 1-3)
Grade
(High vs. Low-grade)
52/4/3 < 0.0001
In colon cancer, the expression of Leptin is associated with negative lymph node metastasis [19]. Colon cancer Leptin
(positive vs. negative)
Nodal status (N0 vs N1-N3) 52/4/3 < 0.0001
In gastric cancer patients, HDAC2 expression was associated with negative lymph node metastasis [20]. Stomach caner HDAC2 expression
(positive vs. negative)
Nodal status (N0 vs N1-N3) 50/3/2 < 0.0001