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Table 2 Five topics with highly populated drugs (>70%) in a therapeutic category

From: Mining FDA drug labels using an unsupervised learning technique - topic modeling

Topics

Statistics

Corresponding ADRs from MedDRA

 

# drugs

Therapeutic categories (First Level of ATC)

%

P-value

 

Topic 1

31

Antineoplastic and immunomodulating agents (L/24)

81%

0.0005

Neutropenia; stomatitis; infection; myelosuppression; sepsis; immunosuppression

Topic 4

21

Antiinfectives for systemic use (J/19)

96%

0.0005

Colitis; diarrhea; allergy; colectomy; eosinophilia

Topic 6

20

Nervous system (N/14)

73%

0.0011

Suicide; irritability; restlessness; agitation; anxiety

Topic 18

14

Nervous system (N/11)

88%

8.31E-004

Death; psychosis; elderly; dementia; extrapyramidal symptoms

Topic 22

12

Nervous system (N/8)

75%

0.020

Depression; excitement; dysphoria; unconsciousness; sleep disturbances