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Table 3 End-to-end distance simulation results for LRP6 intracellular domain.

From: Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway

 

Length

Motifs contained

start-end

∆mean (Constraint1)

∆mean (Constraint2)

     

δ=20

δ=10

δ=5

D1

103aa

S/T cluster; Motif 1

24-126

12.7220

17.5067

21.9135

24.2415

D2

103aa

Motif 1&2

64-166

0.8405

1.9484

2.4047

2.7648

D3

103aa

Motif 1,2&3

106-208

-1.3586

-2.7764

-2.8862

-3.0856

D4

103aa

Motif 2,3&4

124-226

-1.6533

-3.5066

-3.4477

-3.5721

D5

103aa

Motif 2,3,4 &5

141-243

-1.4545

-3.1360

-3.1388

-3.3186

  1. The table shows the length, motif contained, starting and ending positions in LRP6 simulation sequence, and the differences between the average Rgyr of structural ensembles after each constraint and the initial structural ensemble.