A quantitative analysis of monochromaticity in genetic interaction networks

BMC Bioinformatics

Table 1 Number of protein complexes identified in the three data sets.

	Total complex amount	Amount of positively monochromatic complexes	Amount of negatively monochromatic complexes	p-value for observing this proportion
Lenient	76	26	30	2.18e-05
Intermediate	59	18	25	2.92e-04
Stringent	46	18	28	1.42e-14

For each dataset, this table indicates the number of total protein complexes, complexes that were identified to be positively monochromatic by MP-score and complexes that were identified to be negatively monochromatic by MP-score. A complex was defined as monochromatic if its |MP-score|>0.5. The highly biased background (Table S1 and Figure S1) should reduce the significance of monochromaticity of genetic interactions within protein complexes. However, it was not reflected by MP-score.

ISSN: 1471-2105