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Table 3 Centrality analysis of PPI network

From: Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression

Gene symbol

Disease(s) or essential gene*

Gene function(s)

Sum of ranks**

UBC

S

• ubiquitin C

7

ACTB

S

• actin, beta

15

UBB

S

• ubiquitin B

29

APP

E

• amyloid beta (A4) precursor protein

32

FOS

S

• v-fos FBJ murine osteosarcoma viral oncogene homolog

51

HSPA4

S

• heat shock 70kDa protein 4

54

PARK2

SD

• Parkinson disease (autosomal recessive, juvenile) 2, parkin

67

SYK

B

• spleen tyrosine kinase

97

TUBB2A

E

• tubulin, beta 2A

117

TSC2

S

• tuberous sclerosis 2

127

UCHL1

E

• ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

217

MARK3

S

• MAP/microtubule affinity-regulating kinase 3

236

RPS27A

S

• ribosomal protein S27a pseudogene 12; ribosomal

355

DNM1

E

• dynamin 1

476

IRS2

E

• insulin receptor substrate 2

497

GNAI2

S

• guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

519

SMARCC2

B

• SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

525

HRAS

S

• v-Ha-ras Harvey rat sarcoma viral oncogene homolog

527

SAT1

S

• spermidine/spermine N1-acetyltransferase 1

529

CRKL

B

• v-crk sarcoma virus CT10 oncogene homolog (avian)-like

531

  1. The L1PPI network (not shown) was constructed by abnormally expressed disease markers, tissue-specific “essential” genes
  2. *The listed genes were found abnormally expressed in samples of schizophrenia (S), bipolar disorder (B) or major depression (D), or were tissue-specific “essential” (E) genes.
  3. **The sum of centrality ranks calculated using various centrality algorithms for the disease and “essential” genes shown in Figure 2.