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Table 1 List of successful targets in helminths and corresponding drug class known to be active against those target.

From: In silico approach to screen compounds active against parasitic nematodes of major socio-economic importance

S.No Target Biochemical class BLAST score Drug family
1. Nicotinic acetylcholine receptor beta 1 Ion transport E: 7e-27
62% identity with human NAch receptor beta 2
Cholinergic Agents
2. Glutamate-gated chloride channel Ion transport E: e-137
54% similarity with human glutamate receptor
Macrolides
3. Glutathione S-transferase Transferases transferring alkyl or aryl groups E: 6e-47
61% identity with human Mu isoform
Isoquinolines
4. Tubulin beta E: 0
96% similarity to human tubulin beta
Benzimidazoles
5. Gamma-aminobutyric acid receptor Chloride channel Piperazines