Performance of the structural-based method. In panel (A), ROC curves of the sequence (SVM-SEQ) and structure-based methods (SVM-3D). The plot shows the improvement of 3% in AUC and 7% in TPR when sequence and structure base methods are compared. In panel B, accuracy and correlation coefficient of SVM-3D as function of the Reliability Index (RI). If predictions with RI>5 are selected the SVM-3D method results in 91% overall accuracy 0.82 correlation coefficient over 78% of the dataset. Accuracy measures (Q2, C, TPR and FPR) are defined in Methods section. DB is the fraction of the whole dataset of mutations.