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Table 4 Comparison with other methods on the KIN dataset.

From: Improving the prediction of disease-related variants using protein three-dimensional structure

  Q2 P[D] S[D] P[N] S[D] C AUC PM
SIFT 0.80 0.90 0.84 0.58 0.69 0.50 0.81 99
PolyPhen2 0.80 0.88 0.86 0.60 0.63 0.48 0.81 98
SVM-SEQ 0.81 0.87 0.88 0.63 0.62 0.50 0.82 100
SVM-3D 0.83 0.87 0.91 0.69 0.59 0.53 0.83 100
  1. The accuracy measures are defined in Methods section. D and N are disease-related and neutral variants respectively. PM is the predicted fraction of the dataset. Methods are tested on KIN dataset.