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Table 4 Comparison with other methods on the KIN dataset.

From: Improving the prediction of disease-related variants using protein three-dimensional structure

 

Q2

P[D]

S[D]

P[N]

S[D]

C

AUC

PM

SIFT

0.80

0.90

0.84

0.58

0.69

0.50

0.81

99

PolyPhen2

0.80

0.88

0.86

0.60

0.63

0.48

0.81

98

SVM-SEQ

0.81

0.87

0.88

0.63

0.62

0.50

0.82

100

SVM-3D

0.83

0.87

0.91

0.69

0.59

0.53

0.83

100

  1. The accuracy measures are defined in Methods section. D and N are disease-related and neutral variants respectively. PM is the predicted fraction of the dataset. Methods are tested on KIN dataset.
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BMC Bioinformatics

ISSN: 1471-2105

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