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Table 1 Summary of the calculation results for the top 10 predictions of bioassay targets and the literature that confirm them as potential drug targets.

From: The BioAssay network and its implications to future therapeutic discovery

Gene Symbol

Degree

Literature Evidence

SULT1E1

1.4744

5.1837

17

Confirmed [19]

WEE1

1.3499

3.1641

47

Confirmed [20]

RGS7

1.3440

3.0462

20

Confirmed [21, 22]

SMN2

1.6241

5.8903

28

Confirmed [23]

RNGTT

1.7738

4.2353

100

Not yet

STK16

1.6785

3.9232

34

Not yet

PAK7

1.7091

3.8467

30

Confirmed [24]

NEK2

1.7952

3.5328

47

Confirmed [25]

YWHAG

1.8603

3.3451

339

Not yet

MAPK10

1.6685

3.0371

27

Confirmed [26]

  1. drug targets, and (d) disease genes at each shortest distance in the human PPI network, compared with the corresponding randomized expectation.