Figure 3
From: A Hidden Markov Model for Copy Number Variant prediction from whole genome resequencing data
Theoretical power of detecting CNVs. Heat-map shows the dependence of power on deletion size (y-axis) and depth-coverage (x-axis). Read size S is fixed at 35bp. Type I error cutoff is 10-5. (a) Power of detecting CNVs based on depth-coverage only. The deletion size R is in the range of 50bp to 256Kbp. The depth-coverage λ is in the range of 0.1 to 5×. (b) Power of detecting CNVs based on mate-pair distance from insert library with mean 200bp and standard deviation 20. (c) Power of detecting CNVs based on mate-pair distance from insert library with mean 1500bp and standard deviation 200.